Circular RNA expression and association with the clinicopathological characteristics in papillary thyroid carcinoma
Dan Guo Fangyuan Li Xiaoxiao Zhao Bo Long Sumei Zhang Anqi Wang Dingyan Cao Jian Sun Binglu Li

"Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Circular RNAs (circRNAs)
are a novel class of RNAs, with higher stability and tissue specificity, which may be of value as novel clinical markers."

Oncol Rep. 2020 Aug;44(2):519-532. 

PIWI-interacting RNAs piR-13643 and piR-21238 are promising diagnostic biomarkers of papillary thyroid carcinoma
"Zhengyan Chang, Guo Ji, Runzhi Huang, Hong Chen, Yaohui Gao, Weifeng Wang, Xuechen Sun, Jie Zhang, Jiayi Zheng, Qing Wei"

piR-13643 and piR-21238 were observed to be significantly upregulated in human PTC. PIWI-interacting RNAs could serve as promising novel biomarkers for accurate detection of PTC.

Aging (Albany NY). 2020 May 19;12(10):9292-9310.

Frequent KRAS Mutations in Oncocytic Papillary Renal Neoplasm With Inverted Nuclei
Kuo Tong, Wei Zhu, Hua Fu, Fang Cao, Shu Wang, Wenxuan Zhou, Chongmei Liu, Dongliang Chen, Songqing Fan, Zhongliang Hu

These results imply that the tumour potentially originates from the distal tubule, especially from the cortical collecting duct, and probably retains its cell polarity, except for nuclear inversion. We therefore propose that oncocytic papillary renal neoplasm with inverted nuclei(OPRNIN) is a better name for this tumour type. OPRNIN is a kidney site-specific KRAS mutation neoplasm different from conventional papillary renal cell carcinoma.

Histopathology. 2020 Jun;76(7):1070-1083.  

Sputum Cell-free DNA: Valued Surrogate Sample for Detection of EGFR Mutation in Patients with Advanced Lung Adenocarcinoma
ZhengWang, LinZhang, LinLi, XiaoguangLi, YanXu, MengzhaoWang, LiLiang, PengJiao, YuanmingLi, ShurongHe, JunDu, LeiHe, MinTang, MingjunSun, LiYang, JingDi, GuanshanZhu, HongShi, DonggeLiu

"Sputum is common cytological sample type, but its potential use in EGFR mutation detection in patients with lung cancer is not fully evaluated. An improved sputum  cfDNA extraction method was established in this study, and  applied super-amplification refractory mutation system (SuperARMS) to detect the EGFR mutation status in sputum cfDNA."

J Mol Diagn. 2020 May 11;S1525-1578(20)30318-4.

Active HPV Infection and Its Influence on Survival in Head and Neck Squamous-Cell Cancer
Anna Janecka-Wid?a, Anna Mucha-Ma?ecka, Kaja Majchrzyk, Krzysztof Halaszka, Marcin Przewo?nik, Dorota S?onina, Beata Biesaga

"High prevalence of HPV-driven HNSCC (mostly within oropharynx) was detected, with HPV16 type the most
frequent, followed by HPV35 and HPV18. The presence of active HPV infection improved survival of both oropharyngeal and non-oropharyngeal cancer patients and should be taken into account in treatment planning."

J Cancer Res Clin Oncol. 2020 May 5.

"Clonality analysis and IDH1 and IDH2 mutation detection in both components of dedifferentiated chondrosarcoma, implicated its monoclonal origin"
Tingting Yang, Yueqing Bai, Jie Chen, Keyang Sun, Yanli Luo, Wentao Huang, Huizhen Zhang

The results of clonality analysis showed that the same X chromosome inactivation and consistent mutation states of the IDH1 and IDH2 genes in the two DDCS components. We conclude that the two DDCS components originate from the same primitive cell and that DDCS is monoclonal in origin.

"Journal of Bone Oncology  Available online 4 May 2020"

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